看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。1 Z2 Q5 b* V6 R; o) w) Y. j1 R
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" a, R9 x' v3 V+ _: t! C3 \Currently available feasibility data for possible combination strategies. - y$ r/ t, Q! G1 C
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Combination Feasibility according to preliminary data ( Q7 l3 ^8 m Q8 t9 T
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Bevacizumab + sorafenib Yes, reduced dose , `# j6 [' O8 S# g4 O6 w- E8 R
Bevacizumab + sunitinib† No - O" m- \8 w- P2 H; T2 C
Bevacizumab + temsirolimus Yes % o- F. n7 K7 L' Q8 K! w! ?
Bevacizumab + everolimus Yes
/ f# ? j: E+ [$ g xSorafenib + sunitinib ? 8 f- `0 N/ R5 l) \6 r: t
Sorafenib + temsirolimus Yes, reduced dose
7 x# h7 U+ w# ]; F, rSorafenib + everolimus Yes, reduced dose 4 Y+ w; q2 f+ ?' w7 ? ^
Sunitinib + temsirolimus† No
' ~& ` \2 A4 A oSunitinib + everolimus ?
1 x! {' C4 t- S8 V% F* FTemsirolimus + everolimus ?
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†Led to US FDA warning.
0 u; j1 t3 U3 j?: As yet unattempted combination.3 p- V! I1 O- R! a
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